Description of the method
Development > Lavage apparatus
Cytostatic lavage of the abdominal cavity is a new method of treating patients during and after surgery, originally developed for malignant tumors of the peritoneum, but currently applied with good results during other challenging surgical procedures. While surgery usually occurs when removing the tumor to release cells, which can adhere to surfaces early and subsequently grow. Additionally, when the operation can be removed only visible structures, while the microscopic escape attention. To avoid their new growth, it is necessary residues tumor as soon as possible. For now, the most effective method of disposal is a new method of lavage of the abdominal cavity known as "Hyperthermic cytostatic intraoperative intraperitoneal lavage of the abdominal cavity," called the international abbreviation "HIPEC" (or HITOC- lung lavage).
The method is particularly suitable for the treatment of malignant tumors in the abdominal cavity (gastrointestinal and gynecological organs).The principle of the lavage consists of filling the abdominal cavity of the by patient cytostatic solution and keeping the temperature around 43°C. This process incorporates two important principles that are required to destroy small tumor cells. Thermotoxicity, cytotoxicity and their interaction with a multiplying effect. Principle of thermotoxicity: During heating of healthy tissue cytostatic agent to a temperature of 43°C, it is on blood circulation, so as to divert excess heat and thereby cools down the cytostatic solution. Tumors pseudomyxoma type and the like is unlike normal tissue when heated cytostatic solution to a temperature of 43°C, preventing covers its surface with a protective layer of protein (heat shock protein), as opposed to healthy tissue by the tumor tissue could dissipate heat. The protein layer of tumor tissue however makes the immune system, which it can be identified as an intruder and effectively combat it.
Cytotoxicity is a chemical treatment of small microscopic tumors by strong solution cytostatics (800-1000x more concentrated than for intravenous process). The intention is elevated concentration of a cytostatic that as lavage liquid of thermotoxicity received in suprathreshold concentration to the "root" of the tumor. The critical period for action of the cytostatic solution is 30 to 35 min from the beginning of its application, when the cytostatic solution saturated with (runs) and how contact with the tumor as well as healthy cells lapped (lavage) internal tissues. After a rest period lavage, another 60 minutes, it applied the principle remains thermotoxicity. Given the natural thermoregulation of the human body, the cytostatic solution into the abdominal cavity continuously cooled by actual body temperature of the patient. For these reasons, the cytostatic solution is recirculated through a special heat exchanger in which it is reheated to a temperature of 43°C. The process of effective interaction heated cytostatic solution is practice set for around 90min (For more information on www.surgicaloncology.com or www.peritonectomy.com).