PIPAC – PRESSURIZED INTRAPERITONEAL AEROSOL CHEMOTHERAPY
PITAC – PRESSURIZED INTRATHORACIC AEROSOL CHEMOTHERAPY
A Comprehensive Guide to the Physics of Aerosol Chemotherapy
MCR-4 TOPOL® represents a modern technology for precise aerosolization, designed with an emphasis on reliability, stability, and accuracy. Its construction offers consistent and predictable results, built on a combination of technical simplicity, robust engineering, and thoroughly validated physical parameters. MCR-4 TOPOL® provides professionals with the confidence that they are working with a tool that respects the realities of practice and the demands of modern medicine.
MCR-4 TOPOL®
The disposable, minimally invasive second-generation surgical atomizer has been specially developed for the most challenging clinical areas of pressurized intraperitoneal and intrathoracic chemotherapy.
PREMIERE FEATURES OF second-generation MICRO-ATOMIZERS
Compared to their predecessors, second-generation surgical micro-atomizers are characterized by:
High-safety construction and design:
- with diameter reduced to 8 mm,
- smooth shape without interfering transition elements,
- ergonomic and safe grip,
- presence of aerosol residue drain hose.
High reliability and durability:
- integrated particulate filter,
- composite and homogeneous mechanism,
Modified spray parameters:
- wider range of pressure levels,
- increased spray angle,
- increased particle size and weight,
- higher droplet velocity,
- enhanced droplet impact,
- increased spray stability,
- faster dosing.
FOCUSED ON SAFETY-ORIENTED DESIGN
MCR-4 TOPOL® has been developed with attention to mechanical robustness, stable handling, and reliable aerosol generation. Its construction aims to support consistent device performance during procedures and to provide a predictable technical workflow for the surgical team. The device’s solid body and internally stable geometry are engineered to help maintain stable aerosol characteristics under defined operating parameters.
SMOOTH EXTERNAL SHAPE FOR CONTROLLED MANIPULATION
The outer surface of MCR-4 TOPOL® is designed without external threads, protrusions, or abrupt changes in diameter. This clean design facilitates smooth insertion and withdrawal through standard ports and may help reduce mechanical resistance during handling. The seamless external profile supports comfortable manipulation in situations where space is limited.
CONTROLLED DROPLET SIZE DISTRIBUTION
MCR-4 TOPOL® generates droplets in the range of approximately 50 μm under defined operating conditions. This droplet size range is commonly referenced in aerosol science for its predictable physical behavior within enclosed environments. The objective of this design is to support repeatable aerosol formation and to contribute to controlled deposition patterns according to the physical parameters applied during use.
MECHANICAL RESISTANCE OF THE DEVICE BODY
The device body is tested for resistance to internal pressure according to the manufacturer’s specifications. Its solid, single-piece construction is designed to limit the presence of internal mechanical junctions. The resulting mechanical stability supports long-term durability and reduces the number of components that may require functional verification prior to use.
DESIGN WITHOUT MOVING INTERNAL PARTS
MCR-4 TOPOL® contains no internal moving components within the atomizing body. By using a solid internal design without sliding seals, synthetic rubber elements, or internal threaded assemblies, the device aims to reduce potential points of mechanical wear. This approach supports predictable performance under standard operating conditions.
A DESIGN ENGINEERED FOR EASY ACESS EVEN IN ANATOMICALLY CHALLENGING AREAS
When working inside laparoscopically accessible cavities, one of the practical requirements is the ability to handle instruments even in spaces that are limited, difficult to orient within, or shaped by anatomical structures forming deep or narrow recesses. For this reason, the MCR-4 TOPOL® has been designed to support controlled guidance and precise orientation of the device, even under demanding spatial conditions.
ENGINEERED SPRAY GEOMETRY
The device produces a hollow-cone spray pattern based on the internal geometry of the atomizing section. This spray form is one of several geometries applied in aerosol technologies, and it is designed to produce a defined distribution profile corresponding to the device’s setup parameters. The hollow-cone structure helps maintain a controlled balance between central clearance and peripheral deposition, reflecting the technical principles used in the construction of the nozzle.
SPRAY PATTERN AS A TECHNICAL OUTPUT
The spray pattern generated by MCR-4 TOPOL® reflects the internal geometry and operating parameters of the device. Regularity and repeatability of the spray pattern are engineering objectives during production and quality control. Visual spray pattern evaluation provides a technical indication of manufacturing precision and consistency of droplet distribution under standardized test conditions.
SPRAY PATTERN
Spray pattern is the most revealing indicator of an atomizer’s precision and in this regard, MCR-4 TOPOL® sets the absolute standard. Its spray geometry is exceptionally uniform, clean, and perfectly repeatable, reflecting the precise engineering of the entire system and the exact balance of all physical parameters. Every spray pattern exposes the true character of an atomizer: whether it generates dangerous hotspots, whether the distribution deviates, or whether it exhibits local instabilities. MCR-4 TOPOL® delivers a spray pattern that is remarkably consistent and stable, confirming its technical maturity and its ability to generate aerosol without local overloads or unwanted concentrations. Here, the regularity of the spray pattern is not just a visual mark of quality—it is tangible evidence that the system performs exactly as intended and can be manufactured with reliable repeatability.
USE IN CLINICAL PRACTICE
Since 2021, MCR-4 TOPOL® has been supplied to facilities in several countries. The device has been incorporated into routine procedural workflows according to local clinical protocols and user requirements. Feedback from international users has contributed to further refinement of the manufacturing process and technical documentation.
DESIGN BASED ON PRINCIPLES OF AEROSOL SCIENCE
The internal geometry of the MCR-4 TOPOL® atomizer is constructed in accordance with established principles of aerosol mechanics relevant to enclosed pressurized environments. These principles guide the control of droplet formation, flow channels, and distribution characteristics. The resulting design reflects a technical application of these concepts to achieve stable aerosol behavior under defined conditions.
CERTIFICATION AND MATERIAL SAFETY
All materials used in the atomizing flow path comply with the applicable requirements for biocompatibility testing according to the relevant standards. The device does not incorporate internal synthetic seals or epoxy adhesives in the aerosol channel. The certification process includes mechanical testing, biocompatibility assessment, and verification of manufacturing quality.
ACCESSIBLE AND TRANSPARENT PRICING POLICY
The manufacturer aims to offer transparent pricing adapted to the economic conditions of different regions and healthcare systems. The goal is to support facilities in adopting technologies consistent with modern aerosol science while considering practical and economic factors.
Independent measurements performed by the Faculty of Mechanical Engineering of the Brno University of Technology.
PROUDLY DEVELOPED AND MANUFACTURED IN CZECH REPUBLIC
AVAILABLE INDUSTRIAL VARIANTS
For non-clinical industrial, laboratory, or research applications, additional variants of the MCR-4 TOPOL® platform can be manufactured upon customer request. These include multiple configurations designed for technical or scientific use outside the medical field.
